Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9859293 | 0.81 | MEN1 (0.47) | GPBAR1RAPGEF3NOTUMMEN1KMT2A | |
| SCHEMBL24959794 | 0.80 | NOTUM (0.42) | GPBAR1RAPGEF3NOTUMALDH1A1MRGPRX4 | |
| SCHEMBL9858842 | 0.79 | HDAC1 (0.47) | GPBAR1RAPGEF3NOTUMMRGPRX4KDR | |
| SCHEMBL25403646 | 0.78 | PLOD2 (0.41) | GPBAR1RAPGEF3NOTUMMEN1ALDH1A1 | |
| SCHEMBL23112384 | 0.77 | GSK3B (0.54) | NOTUMMRGPRX4 | |
| SCHEMBL313146 | 0.75 | KIF11 (0.54) | GPBAR1RAPGEF3NOTUMMRGPRX4KDR | |
| SCHEMBL6578591 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MRGPRX4KDRCYP1A2CYP2D6 | |
| SCHEMBL28144725 | 0.74 | NOTUM (0.67) | NOTUMMEN1ALDH1A1KMT2AMRGPRX4 | |
| SCHEMBL9481842 | 0.74 | NPC1 (0.47) | MEN1ALDH1A1KMT2ARAB9A | |
| SCHEMBL665618 | 0.74 | CA12 (0.51) | NOTUMALDH1A1CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153127-B1 | N-ARYL-3-ARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDES, PROCESSES FOR THEIR PRODUCTION, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHODS FOR COMBATTING INSECTS | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4863947-A | PESTICIDES, INSECTICIDES | ROHM AND HAAS (US) | 1989-09-05 | — | — | US | disclosed |
| US-4663341-A | Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides | ROHM AND HAAS COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0153127-A2 | N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides, processes for their production, insecticidal compositions containing them and methods for combatting insects | ROHM AND HAAS COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |