SCHEMBL986334

SCHEMBL986334

O=c1ccn([C@H]2C[C@H](O)[C@@H](C(Br)OP(=O)(O)O)O2)c(=O)[nH]1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DUT P33316 4/20 0.52
P2RY2 P41231 13/20 0.43
P2RY6 Q15077 7/20 0.43
P2RY4 P51582 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL150273 0.90 DUT (0.52) DUTP2RY2P2RY6P2RY4
SCHEMBL475343 0.87 DUT (0.52) DUTP2RY2P2RY6P2RY4
SCHEMBL9765650 0.87 DUT (0.55) DUTP2RY2P2RY6P2RY4
SCHEMBL4444375 0.84 DUT (0.48) DUTP2RY2P2RY6P2RY4
SCHEMBL7031221 0.84 DUT (0.52) DUTP2RY2P2RY6P2RY4
SCHEMBL3340603 0.83 DUT (0.50) DUTP2RY2P2RY6P2RY4
SCHEMBL41471 0.83 DUT (0.50) DUTP2RY2P2RY6P2RY4
SCHEMBL4201158 0.83 DUT (0.50) DUTP2RY2P2RY6P2RY4
SCHEMBL2557435 0.83 DUT (0.50) DUTP2RY2P2RY6P2RY4
SCHEMBL629553 0.83 DUT (0.45) DUTP2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10557169-B2 Pooled adapter strategy for reducing bias in small RNA characterization MOUNT SINAI SCHOOL OF MEDICINE (US) 2020-02-11 US claimed
US-20170051348-A1 POOLED ADAPTER STRATEGY FOR REDUCING BIAS IN SMALL RNA CHARACTERIZATION MOUNT SINAI SCHOOL OF MEDICINE (US) 2017-02-23 US claimed
WO-2009063254-A2 THYMIDINE KINASE ASSAY UNIVERSITY OF ABERTAY, DUNDEE (GB) 2009-05-22 WO claimed
US-20210139947-A1 METHOD FOR ASSESSING SUSCEPTIBILITY OF A VIRUS TO TREATMENT BY MEASURING ENZYME ACTIVITY AND A SYSTEM THEREFORE CAVIDI AB (SE) 2021-05-13 US disclosed
CN-110832083-A Method for evaluating sensitivity of virus to treatment by measuring enzyme activity and system thereof 卡维迪有限公司 2020-02-21 CN disclosed
US-7875422-B2 in an enveloped virus-infected mammalian individual by testing on an enzyme packed into an enveloped virus, such as HIV, recovered from a biological sample, such as blood or plasma CAVIDI AB (SE) 2011-01-25 US disclosed
WO-2009063254-A2 THYMIDINE KINASE ASSAY UNIVERSITY OF ABERTAY, DUNDEE (GB) 2009-05-22 WO disclosed
US-7488577-B2 non-radioactive assay in microtiter plate format enabling colorimetric or fluorimetric product detection for drug screening; solid phase synthesis CAVIDI TECH AB (SE) 2009-02-10 US disclosed
WO-2008024052-A1 A METHOD AND A KIT FOR DETERMINATION OF AN ENZYME ACTIVITY INVOLVED IN METABOLIC PRODUCTION OF A DEOXYNUCLEOSIDE TRIPHOSPHATE AND USE THEREOF RÖNNERBOL INTERNATIONAL AB (SE) 2008-02-28 WO disclosed
EP-1311672-B1 tRNA-derived inhibitors of HIV reverse transcriptase PRIMERT AB (SE) 2006-03-01 EP disclosed
EP-1395675-B1 A METHOD FOR MEASURING DNA POLYMERIZATION AND APPLICATIONS OF THE METHOD CAVIDI TECH AB (SE) 2006-01-18 EP disclosed
US-20040157230-A1 Method for measuring dna polymerization and applications of the method CAVIDI AB (SE) 2004-08-12 US disclosed
US-20040053872-A1 Administering polynucletides that inhibit interactions polymerases with tRNA, to humans for prophylaxis of aquired immune deficiency syndrome PRIMERT AB (SE) 2004-03-18 US disclosed
EP-1395676-A1 VIRAL DRUG SUSCEPTIBILITY TESTING Cavidi Tech AB (SE) 2004-03-10 EP disclosed
EP-1395675-A1 A METHOD FOR MEASURING DNA POLYMERIZATION AND APPLICATIONS OF THE METHOD Cavidi Tech AB (SE) 2004-03-10 EP disclosed
EP-1311672-A1 NEW SEQUENCES Primert AB (SE) 2003-05-21 EP disclosed
WO-2002103039-A1 A METHOD FOR MEASURING DNA POLYMERIZATION AND APPLICATIONS OF THE METHOD CAVIDI TECH AB (SE) 2002-12-27 WO disclosed
WO-2002103040-A1 VIRAL DRUG SUSCEPTIBILITY TESTING CAVIDI TECH AB (SE) 2002-12-27 WO disclosed
WO-2002016608-A1 NEW SEQUENCES PRIMERT AB (SE) 2002-02-28 WO disclosed
US-5053336-A Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1991-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040053872-A1 Administering polynucletides that inhibit interactions polymerases with tRNA, to humans for prophylaxis of aquired immune deficiency syndrome POLRMT, NSUN3, TARBP1 DUT 18/4885P2RY2 1650/4885P2RY6 2303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.