Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24155 | 0.87 | ALDH1A1 (0.52) | CES2CES1RAB9ANPC1ABCG2 | |
| SCHEMBL3361585 | 0.87 | CES2 (0.47) | HPGDCES2CES1ABCG2KDM4E | |
| SCHEMBL1188720 | 0.84 | TPMT (0.61) | HPGDDDR1FFAR2TPMTKDM4E | |
| SCHEMBL1188363 | 0.84 | LMNA (0.47) | HPGDDDR1CES2CES1FFAR2 | |
| SCHEMBL30251625 | 0.84 | TPMT (0.61) | HPGDDDR1FFAR2TPMTKDM4E | |
| SCHEMBL3908308 | 0.82 | CA1 (0.52) | HPGDDDR1RAB9AMAPTNPC1 | |
| SCHEMBL7448823 | 0.82 | PARP1 (0.55) | HPGDDDR1CES2CES1RAB9A | |
| SCHEMBL21807111 | 0.80 | DDR1 (0.41) | HPGDDDR1CES2CES1FFAR2 | |
| SCHEMBL24653922 | 0.80 | BACE1 (0.46) | HPGDCES2CES1RAB9AMAPT | |
| SCHEMBL19024606 | 0.80 | CA1 (0.50) | CES2CES1TPMTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875631-B2 | e.g.1-(3,5-dichlorophenyl)-2-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline; to prevent and/or treat cancer and other abnormal cell growth, and metabolic as well as blood vessel proliferate disorders, in which uncontrolled expression of insulin-like growth factor-1 receptor is observed | ANALYTECON S.A. (CH) | 2011-01-25 | — | — | US | disclosed |