SCHEMBL24155

SCHEMBL24155

COc1cc(OC)cc(C(=O)Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.52
GAA P10253 2/20 0.48
KDM4E B2RXH2 2/20 0.48
ABCG2 Q9UNQ0 1/20 0.48
RXRA P19793 1/20 0.47
CES2 O00748 1/20 0.47
CES1 P23141 1/20 0.47
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
CYP1A2 P05177 2/20 0.44
NPC1 O15118 1/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
RAB9A P51151 1/20 0.44
PARP1 P09874 1/20 0.44
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3361585 0.95 CES2 (0.47) ALDH1A1GAAKDM4EABCG2RXRA
SCHEMBL985849 0.87 CES2 (0.41) ALDH1A1GAAKDM4EABCG2CES2
SCHEMBL19024606 0.87 CA1 (0.50) KDM4ERXRACES2CES1LMNA
SCHEMBL24653922 0.87 BACE1 (0.46) ALDH1A1KDM4EABCG2CES2CES1
SCHEMBL986399 0.87 HPGD (0.44) GAAKDM4EABCG2CES2CES1
SCHEMBL4276392 0.87 P4HB (0.43) ALDH1A1GAAKDM4EABCG2RXRA
SCHEMBL3612973 0.86 NPC1 (0.45) ALDH1A1GAAKDM4EABCG2CES2
SCHEMBL31026223 0.86 NPC1 (0.45) ALDH1A1GAAKDM4EABCG2CES2
SCHEMBL988436 0.86 KMT2A (0.43) ALDH1A1GAAKDM4EABCG2RXRA
SCHEMBL5226850 0.86 CA1 (0.52) ALDH1A1GAAKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 652 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116813454-B Synthetic method of pterostilbene 珠海市柏瑞医药科技有限公司 2024-03-22 CN claimed
CN-116813454-A Synthetic method of pterostilbene 珠海市柏瑞医药科技有限公司 2023-09-29 CN claimed
CN-112358487-B Lappaconitine derivative, and preparation method and application thereof 中国科学院新疆理化技术研究所 2023-08-25 CN claimed
WO-2022099937-A1 LAPPACONITINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF 中国科学院新疆理化技术研究所 2022-05-19 WO claimed
US-20210386906-A1 METHODS AND FORMULATIONS FOR TRANSDERMAL ADMINISTRATION OF DERMAL CONTOURING AGENTS DYVE BIOSCIENCES, INC. (US) 2021-12-16 US claimed
CN-112358487-A Lappaconitine derivative and preparation method and application thereof 中国科学院新疆理化技术研究所 2021-02-12 CN claimed
CN-107840792-A A kind of synthetic method of resveratrol 常州大学 2018-03-27 CN claimed
WO-2005122670-A2 BIOMONITORED SYNTHESIS ROUTE FOR LARGE SCALE PREPARATION OF CARDOL (BILOBOL) AND 11Δ-CARDOL KARDOL INDÚSTRIA QUÍMICA LTDA. (BR) 2005-12-29 WO claimed
EP-1228056-A2 METHOD FOR THE PREPARATION OF CITALOPRAM H. LUNDBECK A/S (DK) 2002-08-07 EP claimed
US-6407267-B1 USING GRIGNARD REAGENT; ANTIDEPRESSANT H. LUNDBECK A/S (DK) 2002-06-18 US claimed
US-20020035277-A1 Method for the preparation of citalopram H. LUNDBECK A/S (DK) 2002-03-21 US claimed
CN-1331685-A Process for the preparation of citalopram LUNDBECK & CO AS H (DK) 2002-01-16 CN claimed
WO-2000012044-A2 METHOD FOR THE PREPARATION OF CITALOPRAM H. LUNDBECK A/S (DK) 2000-03-09 WO claimed
CN-122036735-A Pyrazolo [3,4-d ] pyrimidine-hydroxamic acid derivatives, synthetic method and application 云南大学 2026-05-15 CN disclosed
CN-121949077-A Preparation method of resveratrol and application of resveratrol in meat preservation 浙江天启生化股份有限公司 2026-05-01 CN disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
US-4064254-A ANTIARRHYTHMIC AND ANTISEROTONINE AGENTS MEAD JOHNSON & COMPANY (US) 1977-12-20 US disclosed
US-4001426-A HAVING CORONARY VASODILATOR ACTIVITY SMITHKLINE CORPORATION (US) 1977-01-04 US disclosed
US-4000143-A ANTIARRHYTHMIC AND ANTISEROTONIN AGENTS MEAD JOHNSON & COMPANY (US) 1976-12-28 US disclosed
US-3931195-A ANTIARRHYTHMIA, ANTISEROTONIN MEAD JOHNSON & COMPANY (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020035277-A1 Method for the preparation of citalopram HTR6, HTR1A, HTR1F ALDH1A1 929/4885GAA 2889/4885KDM4E 865/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH ALDH1A1 587/4885GAA 290/4885KDM4E 3565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.