SCHEMBL9865076

SCHEMBL9865076

CC[S+]([O-])c1sc(C(=O)c2ccccc2)cc1C#N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
KMT2A Q03164 4/20 0.42
HPGD P15428 3/20 0.42
MAPT P10636 3/20 0.42
MEN1 O00255 3/20 0.42
CLK1 P49759 2/20 0.36
DYRK1A Q13627 2/20 0.36
DYRK1B Q9Y463 2/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
ADRA2C P18825 1/20 0.35
MAOA P21397 1/20 0.35
ADRA1A P35348 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9865622 0.86 ALDH1A1 (0.42) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL9865184 0.73 USP7 (0.39) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL9865539 0.73 ALDH1A1 (0.54) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL27692898 0.68 CYP1A2 (0.42) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL9866469 0.64 MEN1 (0.55) ALDH1A1KMT2AHPGDMAPTMEN1
Benzophenone SCHEMBL17818513 0.64 ALDH1A1 (0.64) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL8739630 0.63 ALDH1A1 (0.59) ALDH1A1KMT2AHPGDMAPTMEN1
Propionitrile SCHEMBL27647676 0.61 HPGDS (0.72) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL257364 0.61 ALDH1A1 (0.60) ALDH1A1KMT2AHPGDMAPTMEN1
SCHEMBL7489636 0.61 ABCC9 (0.52) ALDH1A1KMT2AHPGDMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4994485-A Seed and soil fungi, bacteria DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1991-02-19 US disclosed
EP-0234622-B1 NEW THIO COMPOUNDS HAVING FUNGICIDAL ACTIVITY DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1990-06-27 EP disclosed
EP-0234622-A1 New thio compounds having fungicidal activity DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1987-09-02 EP disclosed