SCHEMBL9865360

SCHEMBL9865360

CS(=O)(=O)Nc1cccc([S])c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.59
ALDH1A1 P00352 2/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
POLB P06746 1/20 0.54
KIF11 P52732 1/20 0.50
NR3C1 P04150 1/20 0.49
BRD4 O60885 4/20 0.47
HSD17B1 P14061 1/20 0.47
HSD17B2 P37059 1/20 0.47
HTT P42858 1/20 0.46
NR3C2 P08235 1/20 0.46
NPC1 O15118 1/20 0.45
JAK2 O60674 1/20 0.45
RAB9A P51151 1/20 0.45
KDM1A O60341 1/20 0.45
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698855 0.87 KEAP1 (0.70) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL1488105 0.79 KEAP1 (0.59) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL169803 0.79 KEAP1 (0.59) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL9307018 0.79 KEAP1 (0.59) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL391197 0.78 KEAP1 (0.57) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL12811024 0.78 PTGS1 (0.57) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL1488101 0.78 KEAP1 (0.57) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL9770251 0.78 KEAP1 (0.57) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL9307026 0.78 HSD17B2 (0.67) KEAP1ALDH1A1SMN1; SMN2POLBKIF11
SCHEMBL10293008 0.78 KEAP1 (0.57) KEAP1ALDH1A1SMN1; SMN2POLBKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5011938-A Antimicrobials ELI LILLY AND COMPANY (US) 1991-04-30 US disclosed
US-4940718-A BACTERICIDES ELI LILLY AND COMPANY (US) 1990-07-10 US disclosed
US-4902707-A Bicyclic pyrazolidinones, compositions and use ELI LILLY AND COMPANY (US) 1990-02-20 US disclosed
US-4826992-A MICROBIOCIDE INTERMEDIATES ELI LILLY AND COMPANY (US) 1989-05-02 US disclosed
US-4795815-A BACTERICIDES, MICROBIOCIDES ELI LILLY AND COMPANY (US) 1989-01-03 US disclosed
US-4734504-A 1-alkylated diazolidinones ELI LILLY AND COMPANY (US) 1988-03-29 US disclosed
US-4734505-A 1-(alkylated)-2-(acylated)diazolidinones ELI LILLY AND COMPANY (US) 1988-03-29 US disclosed
US-4716232-A 1-(vinyl phosphonate adduct) pyrazolidinones ELI LILLY AND COMPANY (US) 1987-12-29 US disclosed
EP-0203722-A1 Bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-12-03 EP disclosed
EP-0203723-A1 2,3-(dihydro)bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-12-03 EP disclosed
EP-0202794-A1 7-Substituted-2,3-(Dihydro) bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-11-26 EP disclosed
EP-0202046-A1 7-Substituted bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-11-20 EP disclosed