Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | DDX3X | O00571 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794834 | 1.00 | HTR6 (0.61) | HTR6KEAP1ALDH1A1SMN1; SMN2TYRO3 | |
| SCHEMBL698855 | 0.85 | KEAP1 (0.70) | KEAP1ALDH1A1SMN1; SMN2POLBKIF11 | |
| SCHEMBL10138631 | 0.85 | HTR6 (0.57) | HTR6ALDH1A1SMN1; SMN2TYRO3POLB | |
| SCHEMBL8547020 | 0.82 | HTR6 (0.62) | HTR6ALDH1A1POLBDDX3XKDM4E | |
| SCHEMBL11655851 | 0.81 | HTR6 (0.57) | HTR6ALDH1A1SMN1; SMN2POLBDDX3X | |
| SCHEMBL12728616 | 0.80 | HTR6 (0.61) | HTR6ALDH1A1SMN1; SMN2POLBDDX3X | |
| SCHEMBL27861796 | 0.80 | HTR6 (0.61) | HTR6ALDH1A1SMN1; SMN2POLBDDX3X | |
| SCHEMBL16181301 | 0.80 | HTR6 (0.51) | HTR6ALDH1A1SMN1; SMN2TYRO3POLB | |
| SCHEMBL31604298 | 0.80 | HTR6 (0.61) | HTR6ALDH1A1SMN1; SMN2POLBDDX3X | |
| SCHEMBL2446287 | 0.79 | HTR6 (0.56) | HTR6ALDH1A1POLBDDX3XKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 503 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109096152-B | Preparation method of m-methanesulfonamido aniline | 乐平市赛复乐医药化工有限公司 | 2021-01-08 | — | — | CN | claimed |
| CN-108299250-B | Continuous preparation method of m-dialkylaminomethylsulfonylanilide | 江苏迪安化工有限公司 | 2020-09-18 | — | — | CN | claimed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | claimed |
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | claimed |
| US-8614221-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2013-12-24 | — | — | US | claimed |
| US-8354444-B2 | Substituted pyrrolidine-2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | claimed |
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | claimed |
| US-20100152190-A1 | Substituted Pyrrolidine-2-Carboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | US | claimed |
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-04-01 | — | — | US | claimed |
| WO-2010034671-A1 | PYRINE OR PYRAZINE DERIVATIVES FOR TREATING HCV | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-01 | — | — | WO | claimed |
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | claimed |
| US-20100075948-A1 | Substituted Pyrrolidine-2-Carboxamides | DING QINGJIE | 2010-03-25 | — | — | US | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| WO-2025217141-A1 | PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 | ENANTA PHARMACEUTICALS, INC. (US) | 2025-10-16 | — | — | WO | disclosed |
| US-20250313569-A1 | Pharmaceutical Compounds And Compositions As Modulators Of MAS-Related G-Protein Receptor X2 | ENANTA PHARMACEUTICALS, INC. | 2025-10-09 | — | — | US | disclosed |
| US-4025614-A | Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of allergic reactions | SMITHKLINE CORPORATION (US) | 1977-05-24 | — | — | US | disclosed |
| US-3978040-A | Process for the preparation of cyanoazo compounds by reacting halogenoazo compounds with CuCN in an aqueous media in the presence of a nitrogen base | BAYER AKTIENGESELLSCHAFT (DT) | 1976-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250313569-A1 | Pharmaceutical Compounds And Compositions As Modulators Of MAS-Related G-Protein Receptor X2 | MRGPRX2, MRGPRX1, MRGPRX4 | HTR6 673/4885KEAP1 1655/4885ALDH1A1 4719/4885 |
| US-20100152190-A1 | Substituted Pyrrolidine-2-Carboxamides | ARG2, CCNY, PYCR1 | HTR6 3828/4885KEAP1 3810/4885ALDH1A1 2027/4885 |
| US-20100075948-A1 | Substituted Pyrrolidine-2-Carboxamides | ARG2, CCNY, PYCR1 | HTR6 3828/4885KEAP1 3810/4885ALDH1A1 2027/4885 |
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | EIF2AK2, POLR2A, HCCS | HTR6 4016/4885KEAP1 765/4885ALDH1A1 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.