Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867792 | 0.89 | HRH2 (0.53) | HRH2HRH3 | |
| SCHEMBL9867200 | 0.86 | HRH2 (0.53) | HRH2HRH3 | |
| SCHEMBL9866703 | 0.84 | PRMT5 (0.44) | PRMT5WDR77HRH2HRH3 | |
| SCHEMBL9866059 | 0.81 | ADRB1 (0.41) | LMNA | |
| SCHEMBL9866314 | 0.79 | KDM4E (0.43) | PRMT5WDR77 | |
| SCHEMBL9866310 | 0.79 | ABCB1 (0.42) | PRMT5WDR77HRH2HRH3LMNA | |
| SCHEMBL10371356 | 0.79 | ABCB1 (0.42) | PRMT5WDR77HRH2HRH3LMNA | |
| SCHEMBL9867806 | 0.77 | HRH2 (0.49) | HRH2HRH3 | |
| SCHEMBL9866682 | 0.74 | ADRB2 (0.47) | LMNA | |
| SCHEMBL10372620 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |