Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866059 | 0.85 | ADRB1 (0.41) | ADRB2ADRB1CYP1A2CYP2D6ADRB3 | |
| SCHEMBL9865763 | 0.77 | ADRB1 (0.44) | ADRB2ADRB1NR2E1SIGMAR1CYP1A2 | |
| SCHEMBL9866679 | 0.74 | PRMT5 (0.45) | LMNA | |
| SCHEMBL9866779 | 0.73 | CYP1A2 (0.41) | SIGMAR1CYP1A2CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL9867117 | 0.73 | L3MBTL1 (0.43) | SIGMAR1CYP2D6CYP2C9KMT2AKDM4E | |
| SCHEMBL9867346 | 0.72 | HRH3 (0.45) | SMN1; SMN2HTR1BDRD3MEN1KMT2A | |
| SCHEMBL11036952 | 0.72 | HRH2 (0.30) | — | |
| SCHEMBL9865953 | 0.71 | HRH3 (0.44) | SMN1; SMN2TSHRHTR1BDRD3MEN1 | |
| SCHEMBL9709892 | 0.71 | KDM1A (0.40) | ALDH1A1SMN1; SMN2MAPK1LMNAKCNH2 | |
| SCHEMBL9828126 | 0.71 | EPHX2 (0.39) | SIGMAR1HTR2AHTR1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |