Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 13/20 | 0.46 |
| ▸ | CA2 | P00918 | 13/20 | 0.46 |
| ▸ | CA9 | Q16790 | 8/20 | 0.46 |
| ▸ | CA12 | O43570 | 8/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.46 |
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 4/20 | 0.41 |
| ▸ | CA7 | P43166 | 4/20 | 0.41 |
| ▸ | CA5A | P35218 | 3/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867816 | 0.84 | HSD17B1 (0.46) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL9866053 | 0.84 | CA2 (0.43) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL9869169 | 0.84 | CA2 (0.47) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL9866328 | 0.84 | NPC1 (0.49) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL9867067 | 0.84 | ADORA3 (0.56) | CA1CA2CA9CA12CA14 | |
| SCHEMBL9868776 | 0.83 | CYP19A1 (0.40) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL9868864 | 0.80 | KIF11 (0.51) | CA1CA2CA9 | |
| SCHEMBL9867503 | 0.80 | ADORA3 (0.52) | CA1CA2CA9CA12CA4 | |
| SCHEMBL9867247 | 0.79 | CA2 (0.54) | CA1CA2CA9CA12CA14 | |
| SCHEMBL9868652 | 0.78 | SOS1 (0.50) | CA1CA2CA9CA12ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |