Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.54 |
| ▸ | CA1 | P00915 | 13/20 | 0.54 |
| ▸ | CA9 | Q16790 | 12/20 | 0.54 |
| ▸ | CA12 | O43570 | 9/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.54 |
| ▸ | CA5A | P35218 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999360 | 0.85 | MEN1 (0.48) | CA2CA1CA9CA12CA14 | |
| SCHEMBL11423635 | 0.80 | ADORA3 (0.56) | CA2CA1CA9CA12CA14 | |
| SCHEMBL9868097 | 0.79 | CYP19A1 (0.58) | CA2CA1CA9CA12CA14 | |
| SCHEMBL9869169 | 0.78 | CA2 (0.47) | CA2CA1CA9CA12CA5A | |
| SCHEMBL9866328 | 0.78 | NPC1 (0.49) | CA2CA1CA9CA12CA14 | |
| SCHEMBL9866053 | 0.78 | CA2 (0.43) | CA2CA1CA9CA12CA5A | |
| SCHEMBL9867067 | 0.77 | ADORA3 (0.56) | CA2CA1CA9CA12CA14 | |
| SCHEMBL8806142 | 0.76 | XDH (0.45) | MAPTXDHAPPMGAMGAA | |
| SCHEMBL10749315 | 0.76 | CASP3 (0.48) | MAPTXDHAPPMGAMGAA | |
| SCHEMBL9868617 | 0.76 | MAPT (0.43) | CA2CA1CA9CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |