Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ASPH | Q12797 | 2/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869016 | 0.90 | FFAR1 (0.50) | FFAR1SLC22A12SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9869063 | 0.88 | LMNA (0.53) | FFAR1SLC22A12SMN1; SMN2RAB9AGSK3A | |
| SCHEMBL4018089 | 0.84 | CA12 (0.48) | SLC22A12SMN1; SMN2GSK3BTP53MAPT | |
| SCHEMBL10469069 | 0.83 | CA12 (0.57) | SMN1; SMN2RAB9ANPC1USP2GAA | |
| SCHEMBL6290570 | 0.81 | RAB9A (0.67) | FFAR1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL9869415 | 0.81 | LMNA (0.53) | FFAR1SMN1; SMN2RAB9AGSK3AGSK3B | |
| SCHEMBL13058364 | 0.77 | L3MBTL1 (0.59) | FFAR1TP53GAAKDM4EALDH1A1 | |
| SCHEMBL11817237 | 0.76 | FFAR1 (0.47) | FFAR1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL16611699 | 0.75 | HSD17B10 (0.49) | SLC22A12MAPTKDM4EKDM4CALDH1A1 | |
| SCHEMBL20644280 | 0.75 | FFAR1 (0.57) | FFAR1SMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |