Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ASPH | Q12797 | 2/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869231 | 0.90 | FFAR1 (0.50) | FFAR1KDM4EASPHKDM8SMN1; SMN2 | |
| SCHEMBL9869415 | 0.88 | LMNA (0.53) | FFAR1KDM4ESMN1; SMN2RAB9AGSK3A | |
| SCHEMBL3776648 | 0.83 | ALDH1A1 (0.54) | KDM4ESMN1; SMN2RAB9ANPC1KDM4C | |
| SCHEMBL6290570 | 0.81 | RAB9A (0.67) | FFAR1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9869063 | 0.81 | LMNA (0.53) | FFAR1KDM4ESMN1; SMN2RAB9AGSK3A | |
| SCHEMBL20644280 | 0.77 | FFAR1 (0.57) | FFAR1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3780022 | 0.77 | L3MBTL1 (0.59) | FFAR1KDM4EKDM4CTSHRTP53 | |
| SCHEMBL30786144 | 0.76 | FFAR1 (0.47) | FFAR1SMN1; SMN2RAB9ANPC1USP2 | |
| SCHEMBL11826469 | 0.76 | FFAR1 (0.47) | FFAR1SMN1; SMN2RAB9ANPC1USP2 | |
| SCHEMBL1023957 | 0.75 | KDM4C (0.50) | KDM4EKDM4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |