Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532311 | 0.79 | NPC1 (0.38) | GAACYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9867577 | 0.78 | NPC1 (0.48) | L3MBTL1CYP1A2CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL9866354 | 0.78 | MPL (0.40) | L3MBTL1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9865831 | 0.77 | ALDH1A1 (0.46) | L3MBTL1GAACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL9868234 | 0.74 | L3MBTL1 (0.52) | L3MBTL1GAACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL9868332 | 0.74 | PSMB8 (0.45) | CYP1A2CYP2C19CYP3A4MAPK1TDP1 | |
| SCHEMBL11810775 | 0.73 | HSP90AA1 (0.55) | L3MBTL1GAACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL2213825 | 0.72 | ADORA3 (0.59) | L3MBTL1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL9868827 | 0.71 | L3MBTL1 (0.41) | L3MBTL1GAACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL9867475 | 0.71 | CA1 (0.45) | L3MBTL1GAACYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160221985-A1 | METHOD FOR THE PREPARATION OF THIADIAZOLES | BERCOT ERIC A (US) | 2016-08-04 | — | — | US | disclosed |
| US-9296735-B2 | Method for the preparation of thiadiazoles | AMGEN INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150141655-A1 | METHOD FOR THE PREPARATION OF THIADIAZOLES | AMGEN INC. | 2015-05-21 | — | — | US | disclosed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141655-A1 | METHOD FOR THE PREPARATION OF THIADIAZOLES | GAPDH, TALDO1, HOGA1 | L3MBTL1 3367/4885GAA 801/4885CYP1A2 148/4885 |
| US-20160221985-A1 | METHOD FOR THE PREPARATION OF THIADIAZOLES | GAPDH, TALDO1, HOGA1 | L3MBTL1 3367/4885GAA 801/4885CYP1A2 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.