Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PARG | Q86W56 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6020167 | 0.87 | PDE4A (0.56) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL9780583 | 0.87 | ALDH1A1 (0.67) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL9872185 | 0.85 | ALDH1A1 (0.55) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL9870435 | 0.84 | ALDH1A1 (0.74) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL24762016 | 0.80 | GAA (0.57) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL10078758 | 0.80 | ALDH1A1 (0.75) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL12656334 | 0.80 | ALDH1A1 (0.75) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL23683085 | 0.80 | GAA (0.61) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL23683108 | 0.80 | GAA (0.57) | GAAALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL5499591 | 0.80 | ALDH1A1 (0.59) | GAAALDH1A1PKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997847-A | Thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (DE) | 1991-03-05 | — | — | US | disclosed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | disclosed |