Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.74 |
| ▸ | PKM | P14618 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PARG | Q86W56 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021266 | 0.86 | PARG (0.63) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL21048464 | 0.86 | ALDH1A1 (1.00) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL12672471 | 0.86 | ALDH1A1 (1.00) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL8349699 | 0.86 | ALDH1A1 (1.00) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9577143 | 0.86 | ALDH1A1 (1.00) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9872185 | 0.84 | ALDH1A1 (0.55) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9869796 | 0.84 | GAA (0.54) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10453840 | 0.84 | ALDH1A1 (0.96) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9870931 | 0.84 | FBP1 (0.52) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10439296 | 0.82 | ALDH1A1 (0.71) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997847-A | Thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (DE) | 1991-03-05 | — | — | US | disclosed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | disclosed |