Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870867 | 0.79 | GABRA1 (0.42) | CCNE2CCNE1CDK2GABRA1GABRG2 | |
| SCHEMBL11475886 | 0.73 | EGLN2 (0.60) | EGLN2KDM4EALDH1A1KMT2A | |
| SCHEMBL3704252 | 0.69 | ADORA2A (0.41) | CCNE2CCNE1CDK2GABRA1GABRG2 | |
| SCHEMBL3707772 | 0.69 | KDM4E (0.43) | EGLN2CCNE2CCNE1CDK2GABRA1 | |
| SCHEMBL5401149 | 0.67 | CCNE2 (0.41) | EGLN2CCNE2CCNE1CDK2GABRA1 | |
| SCHEMBL5401154 | 0.67 | FLT3 (0.54) | CCNE2CCNE1CDK2GABRA1GABRG2 | |
| SCHEMBL11009860 | 0.67 | BACE1 (0.62) | EGLN2CDK8ROCK1ADORA2ABACE1 | |
| SCHEMBL9869668 | 0.67 | EGLN2 (1.00) | EGLN2BACE1KDM4EALDH1A1KMT2A | |
| SCHEMBL2274673 | 0.66 | EGLN2 (0.44) | EGLN2KDM4EALDH1A1SCN9ANPC1 | |
| Hydrochloric Acid SCHEMBL11014780 | 0.66 | BACE1 (0.61) | EGLN2CDK8ROCK1ADORA2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | claimed |
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | disclosed |