Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945604 | 0.86 | TXNRD1 (0.42) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL8862330 | 0.81 | TDP1 (0.52) | ALDH1A1TDP1TSHRLMNAHSD17B10 | |
| SCHEMBL5698334 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL546059 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL29471399 | 0.79 | HSD17B10 (0.56) | ALDH1A1TDP1TSHRLMNAHSD17B10 | |
| SCHEMBL1513945 | 0.79 | HSD17B10 (0.56) | ALDH1A1TDP1TSHRLMNAHSD17B10 | |
| SCHEMBL9339650 | 0.79 | ALDH1A1 (0.49) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL11641276 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL11878505 | 0.78 | PLAU (0.54) | ALDH1A1TDP1CYP3A4POLBMEN1 | |
| SCHEMBL11232668 | 0.77 | GPR35 (0.50) | ALDH1A1TDP1CYP3A4TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230116771-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2023-04-13 | — | — | US | disclosed |
| EP-3408271-B1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMA (US) | 2023-01-11 | — | — | EP | disclosed |
| US-11446389-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| CN-108779127-B | Maytansinoid derivatives, conjugates thereof, and methods of use | 里珍纳龙药品有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114478801-A | Maytansinoid derivatives, conjugates thereof, and methods of use | 里珍纳龙药品有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20200121806-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2020-04-23 | — | — | US | disclosed |
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2019-11-05 | — | — | US | disclosed |
| EP-3408271-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | Regeneron Pharmaceuticals, Inc. (US) | 2018-12-05 | — | — | EP | disclosed |
| US-20180289834-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2018-10-11 | — | — | US | disclosed |
| US-9950076-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-4992471-A | Fluorinated carboxanilide | LILLY INDUSTRIES LIMITED (GB) | 1991-02-12 | — | — | US | disclosed |
| US-4962284-A | HERBICIDES, FUNGICIDES | ELI LILLY AND COMPANY (US) | 1990-10-09 | — | — | US | disclosed |
| US-4826841-A | INSECTICIDES, MITICIDES | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |
| CN-87102456-A | MOLLUSCICIDES | — | 1987-09-30 | — | — | CN | disclosed |
| EP-0238351-A2 | Molluscicides | LILLY INDUSTRIES LIMITED (GB) | 1987-09-23 | — | — | EP | disclosed |
| CN-86102262-A | The preparation of N-alkane arginyl polyaniline and application thereof | — | 1986-11-19 | — | — | CN | disclosed |
| EP-0197756-A2 | Alkanoyl anilides | ELI LILLY AND COMPANY (US) | 1986-10-15 | — | — | EP | disclosed |
| EP-0197451-A2 | Energy submetering system | HONEYWELL INC. (US) | 1986-10-15 | — | — | EP | disclosed |
| US-4088766-A | PRODUCTION OF PROSTAGLANDINS IN MAMMALS | THE UPJOHN COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4001256-A | PROSTAGLANDIN PRODUCTION IN MAMMALS | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885TDP1 1076/4885CYP3A4 1482/4885 |
| US-20230116771-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885TDP1 1076/4885CYP3A4 1482/4885 |
| US-20180289834-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885TDP1 1076/4885CYP3A4 1482/4885 |
| US-20200121806-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885TDP1 1076/4885CYP3A4 1482/4885 |
| US-11446389-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885TDP1 1076/4885CYP3A4 1482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.