Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692340 | 0.86 | MAPT (0.66) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL5692343 | 0.86 | MAPT (0.66) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL10347130 | 0.85 | MAPT (0.55) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL9870605 | 0.81 | KMT2A (0.46) | MAPTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL9871987 | 0.81 | ALDH1A1 (0.47) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL19788211 | 0.80 | KCNJ1 (0.48) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL9872180 | 0.80 | KDM4E (0.52) | LMNAKDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1206362 | 0.80 | CYP4F2 (0.47) | LMNAKDM4EALDH1A1L3MBTL1POLB | |
| SCHEMBL9082982 | 0.80 | CCKBR (0.44) | MAPTLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27490205 | 0.80 | MAPT (0.47) | MAPTLMNAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008285-A | Antiarthritic agent with low gastric irritability side effect | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0159684-B1 | (6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPINYL)PENTANOIC ACIDS AND DERIVATIVES, A PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-27 | — | — | EP | disclosed |
| US-4560701-A | ANTIINFLAMMATORY, ANALGESIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0159684-A2 | (6,11-Dihydro-11-oxodibenz(b,e)oxepinyl)pentanoic acids and derivatives, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-30 | — | — | EP | disclosed |
| EP-0118867-A2 | Substituted 4,10-dihydro-10-oxothieno benzoxepins, a method of preparing the same and intermediate thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-09-19 | — | — | EP | disclosed |