SCHEMBL9871849

SCHEMBL9871849

NC(=O)CN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.51
HTT P42858 2/20 0.51
RECQL P46063 2/20 0.51
CYP19A1 P11511 1/20 0.47
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP2D6 P10635 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
DNMT1 P26358 1/20 0.42
EHMT2 Q96KQ7 1/20 0.42
CYP2J2 P51589 1/20 0.42
KCNH2 Q12809 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9873355 0.86 CYP2J2 (0.48) CYP19A1CYP2J2KCNH2
Water SCHEMBL9873813 0.86 NPSR1 (0.54) NPSR1HTTRECQLCYP19A1ALDH1A1
Water SCHEMBL9873819 0.86 NPSR1 (0.54) NPSR1HTTRECQLCYP19A1ALDH1A1
SCHEMBL27615754 0.86 NPSR1 (0.67) NPSR1HTTRECQLALDH1A1KDM4E
SCHEMBL9873774 0.85 CYP2J2 (0.56) MEN1KMT2ACYP2C9CYP2J2KCNH2
SCHEMBL9872298 0.83 NPSR1 (0.57) NPSR1HTTRECQLCYP19A1ALDH1A1
SCHEMBL9786838 0.81 HTT (0.46) NPSR1HTTRECQLCYP19A1ALDH1A1
SCHEMBL9256393 0.80 CYP19A1 (0.49) CYP19A1KCNH2
SCHEMBL9786852 0.78 CYP19A1 (0.50) CYP19A1CYP2J2KCNH2
SCHEMBL9873524 0.77 CYP2J2 (0.58) CYP2C9CYP2J2KCNH2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5057524-A Asthma, dermatitis A. H. ROBINS COMPANY INCORPORATED (US) 1991-10-15 US disclosed