Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873248 | 0.82 | AGTR1 (0.42) | KDM4EAGTR1AGTR2 | |
| SCHEMBL9873687 | 0.81 | AGTR1 (0.43) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9874581 | 0.80 | AGTR1 (0.33) | AGTR1AGTR2GRM2 | |
| SCHEMBL9854477 | 0.80 | AGTR1 (0.45) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9872350 | 0.79 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL9873574 | 0.79 | AGTR1 (0.41) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9873969 | 0.79 | AGTR2 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9879548 | 0.79 | AGTR1 (0.42) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9872818 | 0.79 | AGTR1 (0.42) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9871710 | 0.79 | AGTR1 (0.42) | ALDH1A1KDM4EMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |