Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.33 |
| ▸ | USP1 | O94782 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873248 | 0.87 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9873969 | 0.83 | AGTR2 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9873568 | 0.83 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9872292 | 0.80 | ALDH1A1 (0.41) | AGTR1AGTR2GRM2 | |
| SCHEMBL9872330 | 0.79 | AGTR1 (0.42) | AGTR1AGTR2USP1GRM2HDAC1 | |
| SCHEMBL9874912 | 0.78 | PPARG (0.50) | AGTR1AGTR2 | |
| SCHEMBL9874034 | 0.77 | AGTR2 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9873122 | 0.77 | AGTR1 (0.35) | AGTR1AGTR2USP1 | |
| SCHEMBL9873834 | 0.77 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9873118 | 0.77 | PPARG (0.35) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |