Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9874781 | 0.84 | MTOR (0.38) | RAB9AMTORTSHRTP53ALDH1A1 | |
| SCHEMBL9875122 | 0.77 | NFKB1 (0.33) | POLBRAB9AMTORNFKB1NFKB2 | |
| SCHEMBL9873451 | 0.77 | MTOR (0.37) | POLBRAB9AMTORTSHRKDM4E | |
| SCHEMBL9871258 | 0.77 | MTOR (0.38) | POLBRAB9AMTORTSHRTP53 | |
| SCHEMBL9873755 | 0.75 | MTOR (0.42) | POLBRAB9AMTORTSHRTP53 | |
| SCHEMBL27568549 | 0.72 | POLB (0.35) | POLBTSHRTP53KDM4EALDH1A1 | |
| SCHEMBL2001481 | 0.71 | TSHR (0.52) | POLBRAB9AMTORTSHRTP53 | |
| SCHEMBL17003395 | 0.71 | CA12 (0.45) | RAB9ATSHRALDH1A1HPGDMEN1 | |
| SCHEMBL17003396 | 0.71 | CA12 (0.45) | RAB9ATSHRALDH1A1HPGDMEN1 | |
| SCHEMBL2136871 | 0.71 | ALDH1A1 (0.42) | POLBTSHRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990508-A | Reduced side effects | TOYAMA CHEMICAL CO., LTD. (JP) | 1991-02-05 | — | — | US | disclosed |