SCHEMBL9874248

SCHEMBL9874248

Nc1cc2c(cc1F)sc(=O)n2Cc1ccon1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.34
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
PKM P14618 2/20 0.32
KDM4E B2RXH2 1/20 0.32
TRPA1 O75762 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GRM5 P41594 1/20 0.31
CYP1B1 Q16678 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9685828 0.85 TP53 (0.35) TP53GRIN1GRIN2BL3MBTL1PKM
SCHEMBL9687641 0.79 TMEM97 (0.34) TP53L3MBTL1PKMKDM4EKMT2A
SCHEMBL9686573 0.74 GRIN1 (0.42) GRIN1GRIN2BGRM5
SCHEMBL9687715 0.72
SCHEMBL9831968 0.71 MAPT (0.40) TP53
SCHEMBL8355924 0.71 SHMT2 (0.45) L3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL8362026 0.70 POLB (0.34) L3MBTL1PKMALDH1A1
SCHEMBL10365806 0.65 ALDH1A1 (0.43) KDM4EALDH1A1KMT2A
SCHEMBL9423725 0.63 CNR2 (0.39)
SCHEMBL9372864 0.62 ALDH1A1 (0.32) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5007952-A Herbicidal novel benzothiazolonyl pyrroles NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1991-04-16 US disclosed
EP-0369262-A2 Novel pyrroles NIHON BAYER AGROCHEM K.K. (JP) 1990-05-23 EP disclosed