Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876046 | 0.74 | POLB (0.41) | POLBHPGDCYP19A1KMT2AMEN1 | |
| SCHEMBL9875579 | 0.72 | CYP19A1 (0.36) | CYP19A1KMT2A | |
| SCHEMBL12261482 | 0.71 | TRPM8 (0.38) | NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL11198284 | 0.68 | POLB (0.44) | POLBHPGDCYP19A1KMT2ANPSR1 | |
| SCHEMBL6050416 | 0.67 | ALDH1A1 (0.40) | NPC1RAB9AALDH1A1 | |
| SCHEMBL20516158 | 0.67 | — | — | |
| SCHEMBL1082326 | 0.67 | — | — | |
| SCHEMBL11182405 | 0.67 | ADRA2C (0.40) | POLBHPGDCYP19A1KMT2AMEN1 | |
| SCHEMBL10961074 | 0.67 | POLB (0.51) | POLBHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL6898380 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241232-B1 | ISOXAZOLYLETHANOL DERIVATIVES | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-02-27 | — | — | EP | disclosed |