Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9876420 | 1.00 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BTSHRUSP2 | |
| SCHEMBL9690668 | 0.94 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BTSHRUSP2 | |
| Fumaric Acid SCHEMBL9630586 | 0.94 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BTSHRUSP2 | |
| SCHEMBL9565023 | 0.85 | USP2 (0.43) | ADRA1DADRA1AADRA1BTSHRUSP2 | |
| Oxalic Acid SCHEMBL9687735 | 0.82 | MEN1 (0.42) | ALDH1A1 | |
| Oxalic Acid SCHEMBL9687737 | 0.82 | MEN1 (0.42) | ALDH1A1 | |
| Oxalic Acid SCHEMBL9630637 | 0.81 | MEN1 (0.42) | POLBALDH1A1 | |
| Oxalic Acid SCHEMBL9630643 | 0.81 | MEN1 (0.42) | POLBALDH1A1 | |
| Fumaric Acid SCHEMBL9879661 | 0.80 | MEN1 (0.40) | ALDH1A1 | |
| Oxalic Acid SCHEMBL9807288 | 0.78 | ALDH1A1 (0.41) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |