Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876850 | 0.91 | MAPT (0.47) | CDK2CCNE1CCNA2NPSR1GAA | |
| SCHEMBL9876890 | 0.89 | PTGER1 (0.50) | CDK2CCNE1CCNA2NPSR1GAA | |
| SCHEMBL9876720 | 0.88 | CDK2 (0.46) | CDK2CCNE1CCNA2NPSR1SRC | |
| SCHEMBL9876695 | 0.86 | CCNA2 (0.49) | CDK2CCNA2NPSR1GAASRC | |
| SCHEMBL9876686 | 0.79 | PTGER1 (0.50) | CDK2CCNA2NPSR1GAASRC | |
| SCHEMBL9876897 | 0.77 | KDM4E (0.42) | CDK2CCNA2NPSR1GAASRC | |
| SCHEMBL9876856 | 0.77 | KDM4E (0.43) | CDK2CCNA2NPSR1GAASRC | |
| SCHEMBL9877081 | 0.76 | CCNA2 (0.49) | CDK2CCNA2NPSR1ESR1MAPT | |
| SCHEMBL9877012 | 0.76 | CCNA2 (0.39) | CDK2CCNA2NPSR1GAASRC | |
| SCHEMBL9231716 | 0.75 | CCNA2 (0.38) | CDK2CCNA2NPSR1GAASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006520-A | Antibiotics, antitumor agents, treatment of blood disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |