Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876684 | 0.89 | ESR1 (0.51) | CCNE1CDK2PTGER1ESR1KMT2A | |
| SCHEMBL5487133 | 0.84 | PDE5A (0.54) | CDK2PTGER1KMT2AMEN1GAA | |
| SCHEMBL9876890 | 0.81 | PTGER1 (0.50) | CCNE1CDK2PTGER1KMT2AMEN1 | |
| SCHEMBL20180265 | 0.79 | PTGER1 (0.43) | PTGER1KMT2AMEN1GAAMAPT | |
| SCHEMBL11888545 | 0.77 | CYP11B2 (0.48) | PTGER1KMT2AGAAMAPTPDE5A | |
| SCHEMBL22206289 | 0.77 | LMNA (0.47) | CDK2PTGER1KMT2AMEN1MAPT | |
| SCHEMBL9876930 | 0.76 | CCNE1 (0.49) | CCNE1CDK2PTGER1KMT2AMEN1 | |
| Formamide SCHEMBL16417161 | 0.76 | PTGER1 (0.48) | CDK2PTGER1KMT2AMEN1GAA | |
| SCHEMBL22214575 | 0.75 | ALDH1A1 (0.45) | PTGER1MAPTPDE5AALDH1A1NPSR1 | |
| SCHEMBL22214570 | 0.74 | ALDH1A1 (0.44) | PTGER1MAPTPDE5AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006520-A | Antibiotics, antitumor agents, treatment of blood disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |