Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 7/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10636701 | 0.87 | MAPT (0.39) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL10691575 | 0.81 | RAPGEF4 (0.39) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL9879136 | 0.80 | CYP19A1 (0.42) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL8164756 | 0.80 | CA2 (0.43) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL10900096 | 0.79 | CA2 (0.40) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL10389511 | 0.79 | CYP2D6 (0.42) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL17774684 | 0.78 | HSD17B10 (0.39) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL10595422 | 0.78 | CA2 (0.40) | RAPGEF4KDM4EALDH1A1POLBGAA | |
| SCHEMBL10622343 | 0.78 | RAB9A (0.45) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL10486552 | 0.78 | MME (0.34) | RAPGEF4KDM4EALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992589-A | Substituted phenyl hydroxyethyl sulfones, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |
| EP-0171611-B1 | SUBSTITUTED PHENYLOXETHYL SULPHONES AND PROCESS FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-23 | — | — | EP | disclosed |
| EP-0171611-A1 | Substituted phenyloxethyl sulphones and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-02-19 | — | — | EP | disclosed |