Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879418 | 0.85 | HTT (0.45) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5108684 | 0.80 | KDM4E (0.58) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9965294 | 0.76 | HSD17B10 (0.46) | HTTKDM4ECYP2C19ALDH1A1TSHR | |
| SCHEMBL10870260 | 0.74 | HTT (0.38) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL10870262 | 0.74 | HTT (0.38) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9879119 | 0.72 | HTT (0.48) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL11079720 | 0.72 | POLB (0.56) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9879442 | 0.71 | ALDH1A1 (0.74) | CYP2C9CYP2C19ALDH1A1L3MBTL1MAPT | |
| SCHEMBL22715296 | 0.69 | CSNK2A2 (0.44) | HTTKDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9377414 | 0.67 | HTT (0.47) | HTTKDM4EALDH1A1L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |