Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28981578 | 0.88 | TSHR (0.45) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL23199874 | 0.83 | TSHR (0.52) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL1094363 | 0.83 | TSHR (0.52) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL31261480 | 0.83 | TSHR (0.52) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL13210871 | 0.80 | ESR1 (0.42) | CCR1ALDH1A1ESR1ESR2MEN1 | |
| SCHEMBL12948243 | 0.80 | KMT2A (0.43) | CCR1ALDH1A1ESR1ESR2MEN1 | |
| SCHEMBL953748 | 0.79 | TRPA1 (0.43) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL22323261 | 0.79 | TSHR (0.43) | TSHRTRPA1CCR1ALDH1A1ESR1 | |
| SCHEMBL20569564 | 0.79 | TRPA1 (0.44) | TSHRTRPA1ALDH1A1ESR1ESR2 | |
| SCHEMBL7295721 | 0.79 | TRPA1 (0.43) | TSHRTRPA1CCR1ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114321943-A | Pretreatment method of organic waste liquid | 云南大地丰源环保有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-103664816-B | The one kettle way asymmetric synthesis technique of hiv reverse transcriptase inhibitor Sustiva compounds | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-03-02 | — | — | CN | disclosed |
| EP-2456309-B1 | Azabicyclo[3.2.1]octyl derivatives for use in the treatment of HIV. | GLAXOSMITHKLINE LLC (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2456309-B1 | Azabicyclo[3.2.1]octyl derivatives for use in the treatment of HIV. | GLAXOSMITHKLINE LLC (US) | 2015-12-23 | — | — | EP | disclosed |
| CN-102584801-B | One-pot asymmetric synthesis process of HIV reverse transcriptase inhibitor efavirenz compounds | SHANGHAI INST ORGANIC CHEM | 2015-02-18 | — | — | CN | disclosed |
| US-8592395-B2 | Therapeutic compounds | GLAXOSMITHKLINE LLC (US) | 2013-11-26 | — | — | US | disclosed |
| CN-101454310-B | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI | 2013-07-17 | — | — | CN | disclosed |
| US-20120295877-A1 | Therapeutic Compounds | GLAXOSMITHKLINE LLC | 2012-11-22 | — | — | US | disclosed |
| US-20120295877-A1 | Therapeutic Compounds | GLAXOSMITHKLINE LLC | 2012-11-22 | — | — | US | disclosed |
| US-20120295877-A1 | Therapeutic Compounds | GLAXOSMITHKLINE LLC | 2012-11-22 | — | — | US | disclosed |
| CN-102584801-A | One-pot asymmetric synthesis process of HIV reverse transcriptase inhibitor efavirenz compounds | SHANGHAI INST ORGANIC CHEM | 2012-07-18 | — | — | CN | disclosed |
| EP-2456309-A1 | THERAPEUTIC COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-05-30 | — | — | EP | disclosed |
| US-7994176-B2 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2011-08-09 | — | — | US | disclosed |
| WO-2011011652-A1 | THERAPEUTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011011652-A1 | THERAPEUTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-01-27 | — | — | WO | disclosed |
| EP-2021337-B1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2010-01-13 | — | — | EP | disclosed |
| CN-101454310-A | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI (US) | 2009-06-10 | — | — | CN | disclosed |
| US-20090099182-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY | 2009-04-16 | — | — | US | disclosed |
| EP-2021337-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127726-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295877-A1 | Therapeutic Compounds | CCR5, CCR1, CXCR3 | TSHR 4413/4885TRPA1 1815/4885CCR1 2/4885 |
| US-20090099182-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | TSHR 3078/4885TRPA1 4202/4885CCR1 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.