Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892495 | 0.82 | CSNK2A1 (0.57) | ALDH1A1KDM4EGAACSNK2A1SMN1; SMN2 | |
| SCHEMBL13952292 | 0.82 | CSNK2A1 (0.42) | HPGDALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL19889490 | 0.81 | CSNK2A1 (0.41) | HPGDALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL5264746 | 0.80 | ALDH1A1 (0.39) | HPGDALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL13081779 | 0.77 | KEAP1 (0.44) | HPGDALDH1A1KDM4EPARP1LMNA | |
| SCHEMBL1003845 | 0.75 | MEN1 (0.53) | HPGDALDH1A1KDM4EPARP1CSNK2A1 | |
| SCHEMBL688411 | 0.74 | MAPT (0.56) | ALDH1A1KDM4EUSP2PARP1CSNK2A1 | |
| SCHEMBL1804788 | 0.74 | PARP1 (0.45) | HPGDALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL552239 | 0.74 | CSNK2A1 (0.67) | HPGDALDH1A1KDM4ERAB9APARP1 | |
| Hydrochloric Acid SCHEMBL28266821 | 0.74 | MEN1 (0.52) | HPGDALDH1A1KDM4EPARP1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142692-A1 | ANTIFOLATE COMBINATIONS | CHELSEA THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
| US-20090253719-A1 | CRYSTALLINE SALT FORMS OF ANTIFOLATE COMPOUNDS AND METHODS OF MANUFACTURING THEREOF | CHELSEA THERAPEUTICS, INC. | 2009-10-08 | — | — | US | disclosed |
| CN-1377356-A | Alkylene diamine substituted heterocycles | NEUROGEN CORP (US) | 2002-10-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142692-A1 | ANTIFOLATE COMBINATIONS | DHFR, MTX1, MTHFD1 | HPGD 1121/4885ALDH1A1 316/4885KDM4E 1152/4885 |
| US-20090253719-A1 | CRYSTALLINE SALT FORMS OF ANTIFOLATE COMPOUNDS AND METHODS OF MANUFACTURING THEREOF | SLC7A1, SLC10A1, SLC10A6 | HPGD 1841/4885ALDH1A1 1572/4885KDM4E 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.