Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | DNA2 | P51530 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965549 | 0.81 | TET2 (0.59) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL10839866 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL7509122 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| Hydrochloric Acid SCHEMBL30353212 | 0.75 | ALDH1A1 (0.97) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| Ammonia Solution, Strong SCHEMBL28187483 | 0.75 | ALDH1A1 (0.97) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL11415484 | 0.75 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL13381581 | 0.74 | CSNK2A2 (1.00) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| Fluoride SCHEMBL5823412 | 0.74 | ALDH1A1 (0.94) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL20704965 | 0.73 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDCSNK2A2CSNK2B | |
| SCHEMBL395847 | 0.73 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318703-B2 | Methods for improving kidney function | FIBROGEN, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120149712-A1 | Methods for improving kidney function | FIBROGEN, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149712-A1 | Methods for improving kidney function | ATP6V1B1, REN, GLS | KDM4E 3288/4885ALDH1A1 2566/4885HPGD 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.