Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 5/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HK2 | P52789 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9898696 | 0.80 | EDNRB (0.40) | EGFRKDM4ESMN1; SMN2 | |
| SCHEMBL9898751 | 0.72 | EGFR (0.40) | EGFR | |
| SCHEMBL1067272 | 0.63 | THRB (0.40) | KDM4EMCL1 | |
| SCHEMBL27619310 | 0.63 | ALOX5 (0.57) | EGFRACLYABCC1KDM4ESMN1; SMN2 | |
| SCHEMBL8922452 | 0.63 | CDK4 (0.51) | ACLYABCC1KDM4ECHEK1FGFR1 | |
| SCHEMBL1812020 | 0.62 | PTPN1 (0.45) | ACLYKDM4ESMN1; SMN2 | |
| SCHEMBL28322348 | 0.62 | MAPT (0.44) | EGFRAPAF1MCL1SMN1; SMN2 | |
| SCHEMBL9658181 | 0.62 | ABCC1 (0.48) | ACLYABCC1CHEK1FGFR1CDK4 | |
| SCHEMBL5961843 | 0.61 | CYP3A4 (0.53) | EGFRHTR2CKDM4E | |
| SCHEMBL9379302 | 0.61 | FYN (0.52) | EGFRACLYKDM4ECHEK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013086248-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | TRANSITIONS OPTICAL INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | NQO1, INTS6, IPO4 | EGFR 3417/4885ACLY 2089/4885ABCC1 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.