Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 5/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125699 | 0.81 | FABP6 (0.47) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL3118150 | 0.78 | GDA (0.41) | KDM4EALDH1A1NPC1GAAMAPT | |
| SCHEMBL13519635 | 0.74 | LMNA (0.44) | KDM4EALDH1A1NPC1USP2MAPT | |
| SCHEMBL3126613 | 0.73 | SMN1; SMN2 (0.51) | KDM4EALDH1A1NPC1GAAMAPT | |
| SCHEMBL17184244 | 0.73 | PARP1 (0.55) | KDM4EALDH1A1PARP1 | |
| SCHEMBL20927158 | 0.72 | KDM4E (0.52) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL8237226 | 0.71 | PARP1 (0.47) | ALDH1A1SMN1; SMN2PARP1TNKS2IP6K1 | |
| SCHEMBL4141412 | 0.71 | CDC7 (0.47) | KDM4EALDH1A1NPC1USP2GLA | |
| SCHEMBL8278856 | 0.71 | PARP1 (0.50) | KDM4EALDH1A1NPC1USP2GLA | |
| SCHEMBL8529995 | 0.68 | KDM4E (0.66) | KDM4EALDH1A1NPC1USP2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717734-B2 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof | PHARMAXIS LTD. (AU) | 2020-07-21 | — | — | US | disclosed |
| US-10717734-B2 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof | PHARMAXIS LTD. (AU) | 2020-07-21 | — | — | US | disclosed |
| US-20190119269-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2019-04-25 | — | — | US | disclosed |
| US-20190119269-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2019-04-25 | — | — | US | disclosed |
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-02-12 | — | — | US | disclosed |
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-02-12 | — | — | US | disclosed |
| CN-109153642-A | Indoles and azaindole halogenated allylamine derivatives inhibitors of lysyloxidase and application thereof | 法玛西斯有限公司 | 2019-01-04 | — | — | CN | disclosed |
| EP-3414226-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | Pharmaxis Ltd. (AU) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136871-A9 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136871-A9 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-02 | — | — | US | disclosed |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-02 | — | — | US | disclosed |
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| WO-2015124591-A1 | PYRROLO[3,2] PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-08-27 | — | — | WO | disclosed |
| CN-102574861-B | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| CN-102574861-A | Methylpyrrolopyrimidinecarboxamides | NYCOMED GMBH | 2012-07-11 | — | — | CN | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10717734-B2 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof | IDO1, IDO2, INMT | KDM4E 359/4885ALDH1A1 322/4885NPC1 3010/4885 |
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | IFNG, IFNAR1, IRF3 | KDM4E 2521/4885ALDH1A1 3659/4885NPC1 4057/4885 |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | IFNG, IFNAR1, IRF3 | KDM4E 2521/4885ALDH1A1 3659/4885NPC1 4057/4885 |
| US-20190119269-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | IDO1, IDO2, INMT | KDM4E 359/4885ALDH1A1 322/4885NPC1 3010/4885 |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | KDM4E 271/4885ALDH1A1 863/4885NPC1 4809/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | KDM4E 227/4885ALDH1A1 776/4885NPC1 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.