Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311624 | 0.80 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL311625 | 0.80 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL7432714 | 0.80 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL14423555 | 0.80 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL10028355 | 0.79 | KMT2A (0.39) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL28276234 | 0.78 | ALDH1A1 (0.46) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL14423554 | 0.75 | L3MBTL1 (0.44) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL6706690 | 0.74 | PTPN1 (0.44) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL11489463 | 0.74 | TSHR (0.48) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 | |
| SCHEMBL10028356 | 0.74 | MAPT (0.40) | CYP1A2CYP2C9CYP2C19MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | claimed |
| WO-2012078210-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | NR1H2, NR3C2, ARRB1 | CYP1A2 720/4885CYP2C9 2355/4885CYP2C19 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.