Sugi Predict

Sugi Predict / Compounds / SCHEMBL9900247

SCHEMBL9900247

SCHEMBL9900247

O=C(O)c1cccc2c1C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FTO Q9C0B1 10/20 0.64
▸ MEN1 O00255 4/20 0.64
▸ KMT2A Q03164 4/20 0.64
▸ MAPT P10636 4/20 0.64
▸ TDP1 Q9NUW8 3/20 0.64
▸ HPGD P15428 2/20 0.64
▸ HTT P42858 2/20 0.64
▸ CYP2C19 P33261 1/20 0.64
▸ RECQL P46063 1/20 0.64
▸ BLM P54132 1/20 0.64
▸ SMAD3 P84022 1/20 0.64
▸ PRMT1 Q99873 1/20 0.64
▸ ACE2 Q9BYF1 1/20 0.64
▸ HSD17B10 Q99714 3/20 0.57
▸ ALDH1A1 P00352 3/20 0.57
▸ BRCA1 P38398 2/20 0.57
▸ ALOX12 P18054 2/20 0.57
▸ ALOX15 P16050 2/20 0.57
▸ CYP2C9 P11712 1/20 0.57
▸ POLB P06746 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorescein SCHEMBL11136869 0.86 FTO (0.82) FTOMEN1KMT2AMAPTTDP1
SCHEMBL23002150 0.85 FTO (0.62) FTOMEN1KMT2AMAPTTDP1
SCHEMBL7601752 0.84 FTO (0.70) FTOMEN1KMT2AMAPTTDP1
SCHEMBL16174263 0.83 FTO (0.56) FTOMEN1KMT2AMAPTTDP1
SCHEMBL7955927 0.83 FTO (0.65) FTOMEN1KMT2AMAPTTDP1
SCHEMBL29475314 0.83 FTO (0.65) FTOMEN1KMT2AMAPTTDP1
SCHEMBL23002141 0.83 FTO (0.55) FTOMEN1KMT2AMAPTTDP1
SCHEMBL20832 0.82 ALDH1A1 (0.60) FTOMEN1KMT2AMAPTTDP1
Fluorescein SCHEMBL1110616 0.82 FTO (0.70) FTOMEN1KMT2AMAPTTDP1
SCHEMBL23029210 0.81 MEN1 (0.70) FTOMEN1KMT2AMAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012078308-A1 DEVICES AND METHODS FOR CONCENTRATION AND ANALYSIS OF FLUIDS HALUSHKA PERRY V (US) 2012-06-14 — — WO claimed
US-20230038702-A1 BRIGHT TARGETABLE RED CA2+ INDICATORS HOWARD HUGHES MEDICAL INSTITUTE 2023-02-09 — — US disclosed
US-20210054001-A1 BRIGHT TARGETABLE RED CA2+ INDICATORS HOWARD HUGHES MEDICAL INSTITUTE 2021-02-25 — — US disclosed
US-20140308342-A1 REPROGRAMMING UROKINASE INTO AN ANTIBODY-RECRUITING ANTICANCER AGENT NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-10-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140308342-A1 REPROGRAMMING UROKINASE INTO AN ANTIBODY-RECRUITING ANTICANCER AGENT PLAUR, CD47, CD14 FTO 4418/4885MEN1 2894/4885KMT2A 1637/4885
US-20230038702-A1 BRIGHT TARGETABLE RED CA2+ INDICATORS ATP2A2, ATP2A3, CACNB2 FTO 4539/4885MEN1 1949/4885KMT2A 4415/4885
US-20210054001-A1 BRIGHT TARGETABLE RED CA2+ INDICATORS ATP2A2, ATP2A3, CACNB2 FTO 4539/4885MEN1 1949/4885KMT2A 4415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.