Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2154019 | 0.87 | GLA (0.53) | ALDH1A1GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL6950852 | 0.86 | TSHR (0.52) | ALDH1A1GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL11034403 | 0.84 | GLA (0.51) | GLAKCNJ1KCNH2FFAR1FFAR4 | |
| SCHEMBL28248372 | 0.83 | HTR2B (0.54) | ALDH1A1GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL28865565 | 0.83 | HTR2B (0.50) | ALDH1A1GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL8226207 | 0.83 | GLA (0.50) | ALDH1A1GLAFFAR1FFAR4CYP19A1 | |
| SCHEMBL6962952 | 0.82 | DRD2 (0.49) | ALDH1A1ALOX15GLAKCNJ1KCNH2 | |
| SCHEMBL24358855 | 0.82 | HTR2B (0.49) | HSD17B10GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL29732423 | 0.82 | HTR2B (0.49) | HSD17B10GLAKCNJ1KCNH2FFAR1 | |
| SCHEMBL6960752 | 0.81 | FAAH (0.50) | ALDH1A1ALOX15HSD17B10GLAKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| CN-103347864-A | For treating diseases caused by Lp-PLA2Pyrimidone compounds for mediated diseases or conditions | GLAXO GROUP LTD | 2013-10-09 | — | — | CN | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |