Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.34 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.34 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.34 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373280 | 0.83 | ST14 (0.52) | MAOBST14 | |
| SCHEMBL875696 | 0.83 | LTA4H (0.50) | FAAHSMN1; SMN2SCN9APLAAT3PLAAT5 | |
| SCHEMBL9900498 | 0.82 | SCN9A (0.49) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| Hydrochloric Acid SCHEMBL1713787 | 0.82 | MAOB (0.50) | MAOBST14 | |
| SCHEMBL9103247 | 0.81 | FAAH (0.42) | FAAHSMN1; SMN2SCN9APLAAT3PLAAT5 | |
| SCHEMBL1713357 | 0.80 | CACNA1B (0.39) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL9105782 | 0.79 | PPARD (0.34) | SCN9A | |
| SCHEMBL5534895 | 0.77 | MAPK14 (0.48) | SCN9AMAOB | |
| SCHEMBL9107953 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2SCN9ALMNA | |
| SCHEMBL9106039 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2SCN9ALMNAMAOBLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |