Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375266 | 0.84 | ST14 (0.50) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL9901279 | 0.82 | FAAH (0.36) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL9108961 | 0.81 | PLAAT3 (0.55) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL129948 | 0.81 | TRPV4 (0.52) | MRGPRX4TRPV4DAO | |
| SCHEMBL25383135 | 0.78 | ALDH1A1 (0.50) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL9104744 | 0.77 | SCN9A (0.46) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5534895 | 0.75 | MAPK14 (0.48) | SCN9A | |
| SCHEMBL9106039 | 0.75 | SMN1; SMN2 (0.42) | SCN9A | |
| SCHEMBL15006214 | 0.74 | CYP19A1 (0.51) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL9107191 | 0.74 | KDM4E (0.50) | SCN9APLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |