Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | TGM2 | P21980 | 4/20 | 0.35 |
| ▸ | F13A1 | P00488 | 3/20 | 0.35 |
| ▸ | TGM1 | P22735 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.32 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900927 | 0.82 | KDM1A (0.37) | LMNA | |
| SCHEMBL9942922 | 0.78 | F13A1 (0.37) | CA1CA2TGM2F13A1TGM1 | |
| SCHEMBL9900865 | 0.68 | LMNA (0.43) | CA1CA2P2RX7HPNST14 | |
| SCHEMBL28328057 | 0.66 | LMNA (0.48) | CA1CA2P2RX7LMNAELANE | |
| SCHEMBL9942900 | 0.66 | CTSL (0.44) | CA1CA2P2RX7LMNA | |
| SCHEMBL23540158 | 0.66 | APP (0.50) | CA1CA2TGM2F13A1TGM1 | |
| SCHEMBL5528333 | 0.65 | TLR2 (0.41) | — | |
| SCHEMBL13924823 | 0.64 | NR1H4 (0.49) | TGM2F13A1TGM1LMNAMEN1 | |
| SCHEMBL51559 | 0.63 | CTSS (0.38) | — | |
| SCHEMBL144613 | 0.63 | P2RX7 (0.41) | CA1CA2TGM2F13A1TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649077-A1 | HIV INTEGRASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078834-A1 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-06-14 | — | — | WO | disclosed |