Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31076166 | 0.84 | MEN1 (0.42) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Iodide SCHEMBL28851041 | 0.82 | MEN1 (0.46) | KDM4CMEN1KMT2ACHRNA7L3MBTL1 | |
| Iodide SCHEMBL7755123 | 0.80 | MEN1 (0.49) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Bromide SCHEMBL7324390 | 0.79 | KDM4C (0.47) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Bromide SCHEMBL11517500 | 0.77 | MEN1 (0.49) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Bromide SCHEMBL5214341 | 0.77 | MEN1 (0.49) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Bromide SCHEMBL29196153 | 0.76 | MEN1 (0.44) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL6205586 | 0.76 | KDM4C (0.43) | KDM4CMEN1KMT2AHIF1AL3MBTL1 | |
| Bromide SCHEMBL8442020 | 0.76 | MEN1 (0.51) | KDM4CMEN1KMT2AHIF1ACHRNA7 | |
| Bromide SCHEMBL11354372 | 0.76 | MEN1 (0.51) | KDM4CMEN1KMT2AHIF1ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822542-B2 | Isoketal scavengers and mitigation of disorders involving oxidative injury | VANDERBILT UNIVERSITY (US) | 2014-09-02 | — | — | US | disclosed |
| EP-2477594-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | Vanderbilt University (US) | 2012-07-25 | — | — | EP | disclosed |
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | VANDERBILT UNIVERSITY | 2012-06-21 | — | — | US | disclosed |
| WO-2011008202-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | VANDERBILT UNIVERSITY (US) | 2011-01-20 | — | — | WO | disclosed |
| US-7705054-B1 | Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases | VANDERBILT UNIVERSITY (US) | 2010-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157501-A1 | ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY | PDXK, KYNU, FN3K | KDM4C 1420/4885MEN1 4712/4885KMT2A 3342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.