Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903167 | 0.87 | HTR6 (0.58) | HTR6HTR7HTR2ADRD2HTR2C | |
| SCHEMBL9903789 | 0.86 | HTR7 (0.45) | CHRM2CHRM1HTR6HTR7HTR2A | |
| SCHEMBL9903406 | 0.84 | THRB (0.54) | HTR6HTR7DRD2HTR2CHTR2B | |
| SCHEMBL4690981 | 0.83 | HTR6 (0.61) | HTR6HTR7HTR2ADRD2HTR2B | |
| SCHEMBL9903393 | 0.82 | HTR6 (0.45) | HTR6HTR7HTR2ADRD2HTR2C | |
| SCHEMBL9902532 | 0.80 | ADRA2A (0.44) | HTR6HTR7HTR2ADRD2HTR2C | |
| SCHEMBL9903251 | 0.80 | ADRA2A (0.44) | HTR6HTR7HTR2ADRD2HTR2C | |
| SCHEMBL3558256 | 0.79 | HTR6 (0.72) | CHRM2CHRM1HTR6HTR7HTR2A | |
| SCHEMBL9903357 | 0.77 | HTR6 (0.59) | HTR6HTR7HTR2ADRD2HTR2C | |
| SCHEMBL9903550 | 0.77 | HTR6 (0.47) | HTR6HTR7HTR2ADRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |