Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902644 | 0.82 | LMNA (0.62) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL9329671 | 0.77 | LMNA (0.60) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL8953787 | 0.74 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL9903409 | 0.71 | LMNA (0.58) | SMN1; SMN2LMNANPSR1ALDH1A1ADORA3 | |
| SCHEMBL1067726 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL9432915 | 0.71 | LMNA (0.73) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL9903777 | 0.71 | LMNA (0.62) | SMN1; SMN2LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL9903210 | 0.70 | LMNA (0.56) | SMN1; SMN2LMNAALDH1A1PTGS1PTGS2 | |
| SCHEMBL6643049 | 0.69 | LMNA (0.63) | SMN1; SMN2LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL31403774 | 0.69 | NPC1 (0.42) | SMN1; SMN2LMNAALDH1A1ADORA3GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463277-B1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2017-11-08 | — | — | EP | disclosed |
| CN-105130908-A | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL IND CO | 2015-12-09 | — | — | CN | disclosed |
| CN-102548972-B | Preparation method of 4, 6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO.,LTD. (JP) | 2015-08-19 | — | — | CN | disclosed |
| US-8748605-B2 | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-06-10 | — | — | US | disclosed |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| EP-2463277-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | DPYD, TYMP, DTYMK | SMN1; SMN2 2788/4885LMNA 3856/4885NPSR1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.