Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903178 | 0.88 | HTR3A (0.47) | HTR6HTR7HTR2BDRD2HTR2A | |
| SCHEMBL9903634 | 0.85 | HTR6 (0.50) | HTR6HTR1AHTR7HTR2BCHRNB2 | |
| SCHEMBL4690981 | 0.83 | HTR6 (0.61) | HTR6HTR1AHTR7HTR2BCHRNB2 | |
| SCHEMBL9903675 | 0.82 | HTR6 (0.47) | HTR6HTR1AHTR7HTR2BCHRNB2 | |
| SCHEMBL5067372 | 0.80 | HTR6 (0.70) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL9902743 | 0.79 | HTR6 (0.50) | HTR6HTR1AHTR7CHRNB2CHRNA4 | |
| SCHEMBL3136898 | 0.78 | HTR6 (0.60) | HTR6HTR1AHTR7HTR2BDRD2 | |
| SCHEMBL9903085 | 0.77 | HTR6 (0.57) | HTR6HTR1AHTR7HTR2BCHRNB2 | |
| SCHEMBL9903412 | 0.74 | HTR6 (0.60) | HTR6HTR7HTR2BDRD2HTR2A | |
| SCHEMBL9903925 | 0.74 | HTR6 (0.43) | HTR6HTR1AHTR7DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956004-B1 | Quinoline derivatives and their use as 5-HT6 ligands | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |