Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907341 | 0.85 | HTT (0.48) | KDM4CALDH1A1TP53RAB9AMEN1 | |
| SCHEMBL9907794 | 0.83 | HTR5A (0.45) | PLAU | |
| SCHEMBL9907406 | 0.80 | KDM4C (0.52) | KDM4CIP6K1IP6K3IP6K2ALDH1A1 | |
| SCHEMBL9907326 | 0.79 | PIK3CA (0.57) | KDM4CIP6K1IP6K3IP6K2ALDH1A1 | |
| SCHEMBL9907384 | 0.79 | PLAU (0.46) | KDM4CALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL9907402 | 0.78 | PIK3CA (0.44) | KDM4CIP6K1IP6K3IP6K2ALDH1A1 | |
| SCHEMBL9909203 | 0.77 | ALDH1A1 (0.41) | KDM4CIP6K1IP6K3IP6K2ALDH1A1 | |
| SCHEMBL9909213 | 0.77 | KDM4C (0.46) | KDM4CMAPK1KDM4ECAMKK2TTR | |
| SCHEMBL9907407 | 0.77 | CYP19A1 (0.38) | KDM4CIP6K1IP6K3IP6K2ALDH1A1 | |
| SCHEMBL9907343 | 0.75 | DOT1L (0.42) | KDM4CALDH1A1RAB9ANPC1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | KDM4C 1366/4885IP6K1 4169/4885IP6K3 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.