Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.35 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.35 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907405 | 0.87 | ALOX15 (0.43) | POLBHPGDDYRK1AALDH1A1L3MBTL1 | |
| SCHEMBL9907818 | 0.85 | HTR5A (0.44) | — | |
| SCHEMBL9907402 | 0.83 | PIK3CA (0.44) | SLC22A12POLBIP6K1IP6K3IP6K2 | |
| SCHEMBL9907406 | 0.80 | KDM4C (0.52) | CYP19A1TDP1IP6K1IP6K3IP6K2 | |
| SCHEMBL9907574 | 0.80 | HTR5A (0.43) | TDP1POLBHPGDIP6K1IP6K3 | |
| SCHEMBL9907345 | 0.77 | KDM4C (0.41) | POLBHPGDIP6K1IP6K3IP6K2 | |
| SCHEMBL4641324 | 0.74 | TDP1 (0.50) | CYP19A1TDP1POLBHPGDIP6K1 | |
| SCHEMBL9907403 | 0.74 | JAK2 (0.45) | CYP19A1TDP1SLC22A12POLBHPGD | |
| SCHEMBL9907682 | 0.74 | HTR5A (0.42) | SLC22A12POLBHPGDALDH1A1L3MBTL1 | |
| SCHEMBL9907394 | 0.73 | CSNK2A2 (0.43) | TDP1POLBHPGDIP6K1IP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | CYP19A1 1353/4885TDP1 964/4885SLC22A12 1751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.