Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 4/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 4/20 | 0.45 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909215 | 0.92 | RXRA (0.52) | IP6K1IP6K3IP6K2PTGDR2RXRA | |
| SCHEMBL9907389 | 0.88 | SYK (0.43) | PTGDR2SYKGPBAR1TOP2ANR2E1 | |
| SCHEMBL9907808 | 0.85 | HTR5A (0.45) | PTGDR2TGFB1 | |
| SCHEMBL9909187 | 0.80 | HTT (0.46) | PTGDR2RXRARXRBRXRGGPBAR1 | |
| SCHEMBL9907472 | 0.77 | HTR5A (0.44) | IP6K1IP6K3IP6K2PTGDR2MEN1 | |
| SCHEMBL9907390 | 0.76 | PTGDR2 (0.45) | IP6K1IP6K3IP6K2PTGDR2TOP2A | |
| SCHEMBL9909211 | 0.76 | PTGDR2 (0.45) | IP6K1IP6K3IP6K2PTGDR2TOP2A | |
| SCHEMBL9909279 | 0.76 | HTR5A (0.44) | MAPK1 | |
| SCHEMBL9907326 | 0.76 | PIK3CA (0.57) | IP6K1IP6K3IP6K2MEN1NPC1 | |
| SCHEMBL9909220 | 0.75 | KIF11 (0.50) | IP6K1IP6K3IP6K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | IP6K1 4169/4885IP6K3 4056/4885IP6K2 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.