Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | TET3 | O43151 | 2/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 2/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907446 | 0.83 | NOTUM (0.45) | KDM4EL3MBTL1FTOP4HBKDM6B | |
| SCHEMBL9907435 | 0.80 | KDM4E (0.41) | KDM4EL3MBTL1KDM4AEGLN1HIF1AN | |
| SCHEMBL9907461 | 0.78 | PTGDR2 (0.43) | KDM4ANR1H4KDM4CKDM5AKDM5B | |
| SCHEMBL25210212 | 0.77 | MEN1 (0.36) | SLC6A2KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL9104437 | 0.77 | KDM4E (0.41) | SLC6A2KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL9907414 | 0.77 | TTR (0.47) | SLC6A2KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL21818954 | 0.75 | TRPM5 (0.45) | L3MBTL1ALDH1A1KMO | |
| SCHEMBL7721527 | 0.73 | RXRA (0.41) | SLC6A2P2RY14KDM4EP4HBASPH | |
| Hydrochloric Acid SCHEMBL7981979 | 0.71 | RXRA (0.40) | SLC6A2P2RY14KDM4EP4HBASPH | |
| SCHEMBL1091417 | 0.71 | NCF1 (0.51) | SLC6A2KDM4EL3MBTL1KDM4AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | SLC6A2 56/4885P2RY14 1743/4885KDM4E 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.