Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992158 | 0.90 | HSD11B1 (0.35) | HSD11B1NR1H2HTTMAPTKCNN4 | |
| SCHEMBL991395 | 0.80 | CYP2C19 (0.34) | HTTMAPT | |
| SCHEMBL12950521 | 0.75 | KCNN4 (0.36) | NR1H2MAPTKCNN4 | |
| SCHEMBL116411 | 0.75 | OPRM1 (0.34) | MAPT | |
| SCHEMBL991891 | 0.70 | ALDH1A1 (0.35) | NR1H2HTTMAPTKCNN4 | |
| SCHEMBL11922654 | 0.68 | SMN1; SMN2 (0.57) | — | |
| SCHEMBL991959 | 0.66 | OGT (0.40) | HSD11B1 | |
| SCHEMBL11055846 | 0.66 | CYP2C19 (0.48) | HTTKCNN4 | |
| SCHEMBL1431288 | 0.65 | ALOX5 (0.36) | ALOX5 | |
| SCHEMBL1431286 | 0.65 | ALOX5 (0.36) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440537-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 BASED ON THE 1,3 -OXAZINAN- 2 -ONE STRUCTURE | Vitae Pharmaceuticals, Inc. (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011011123-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 BASED ON THE 1,3 -OXAZINAN- 2 -ONE STRUCTURE | VITAE PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |